Josh Hamilton's slugfest made him the 16th player in MLB history with 4 homers in a game.
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Carlos Delgado, Toronto, Sept. 25, 2003
The last man before Hamilton to homer four times in game, Delgado (seen here in a file photo) went 4 for 4 with six RBIs and the Blue Jays beat Tampa Bay 10-8 in Toronto.